The mechanism of alloxan and streptozotocin action in b. Alloxaninduced diabetes, a common model for evaluating. Pdf hypoglycemic effects of clitoria ternatea linn. Thirty nondiabetic control rats nc and 30 untreated diabetic ud rats were divided into three subgroups sacrificed after 6, 14, or 26 weeks. Hypoglyceamic effect of garcinia kola gk was evaluated in alloxan induced diabetic rats. This study evaluated the longterm effects of alloxaninduced diabetes in rat liver. Sir, we read with interest the article titled anomalies in alloxaninduced diabetic model.
Alloxaninduced diabetes causes morphological and ultrastructural. Coq10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy. Sir, we read with interest the article titled anomalies in alloxan induced diabetic model. The indian journal of pharmacology issn 025376 is an official publication of the indian pharmacological society. Diabetes mellitus can be experimentally induced in vivo for research purposes by streptozotocin or alloxan, which are specifically toxic to beta cells. In research it is used for induction of type 1 diabetes. Effects of methanol extract of chrysophyllum albidum seeds. International journal of pharmaceutical sciences and research. Ethanolic extract of monotes africanus, which is a rich source of various flavonoids has been reported for its antiviral activity against hiv meragelman et al. Pdf protective role of phyllanthus fraternus in alloxan. Effects of diabetes mellitus induced by alloxan on the. The mechanisms of alloxan and streptozotocininduced.
Metformin was metabolized via hepatic cyp2c11, 2d1, and 3a12 in rats. In vitro and in vivo antidiabetic activity of the leaves. Hydroxychloroquine is an immunomodulatory drug that has been used for the treatment of malaria and autoimmune diseases. Potential effect of hydroxychloroquine in diabetes mellitus.
The first evidence for this distinct glucose transport protein was provided by david james in 1988. Pdf the antidiabetic activity of the hf consisting of three wellknown herbs for diabetes namely, piper betel, butea monosperma and. Alloxan induced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals. A mexican study on inhibition of advanced glycation endproduct formation by origanum majorana l. Effects of ece on body weights a and fasting blood glucose levels b in normal and alloxaninduced diabetic rats. Pdf a new model for alloxaninduced diabetes mellitus in rats. Alloxan is widely used to induce experimental diabetes mellitus dm in animals with different grades of disease severity by.
Moringa might lower blood sugar levels in people with diabetes. Effect of coenzyme q10 supplementation on diabetes induced memory deficits in rats. Hyperglycaemic rats were treated with or without oral. Your browser will take you to a web page url associated with that doi name. Research article alloxan induced diabetes mellitus in. Alloxaninduced diabetes delays repair in a rat model of. Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that. Fresh liver weight and its relationship with body weight were. Rosiglitazone increased plasma superoxide dismutase sod activity and, on the other hand, decreased malondialdehyde mda, hscreactive protein, and tumor necrosis factora levels. It is possible to vary the severity of diabetes by using different doses of alloxan, which therefore makes it useful to study the effects of a milder diabetic condition.
Glut4 is the insulinregulated glucose transporter found primarily in adipose tissues and striated muscle skeletal and cardiac. Experimental diabetes induced by alloxan and streptozotocin. This study aims to investigate the therapeutic effects of the aqueous extract of clitoria ternatea linn. Hyperglycaemia was induced in fasted wistar rats with alloxan 150 mgkg body weight. Leta 1899 je svicarski botanik moises santiago bertoni, med raziskovanjem vzhodnega paragvaja prvi podrobno opisal rastlino in njen sladki okus. However, in absence of aggressive stimuli such as ligatures, the influence of diabetes on rat periodontal tissues is incompletely explored. The resulting displaced fracture in diabetic rats requires long periods for remodeling and complete bone consolidation. In diabetes mellitus the body cannot secrete enough insulin or it cannot use its.
We used alloxan to induce diabetes in rats and rabbits for screening the antidiabetic activity of test compounds. Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia. Furthermore 1,25oh 2 d administration in alloxan induced diabetic rats enhances superoxide dismutase, catalase and glutathione peroxidase suggesting a preventive effect against oxidative stress in these diabetic animals by reducing hyperglycemia induced reactive oxygen species production 36. In dmia rats, the protein expression and mrna levels of hepatic cyp2c11 and 3a12 decreased and increased, respectively. Omidi g, karimi sa, rezvanikamran a, monsef a, shahidi s, komaki a. Chemically induced diabetes not only provides a simple and relatively cheap model of diabetes in rodents but can also be used in higher animals dufrane et al. Type 1 diabetes, type 2 diabetes, gestational diabetes, monogenic diabetes, and cystic fibrosisrelated diabetes, latent autoimmune diabetes of adults lada. Watch for signs of low blood sugar hypoglycemia and monitor your blood sugar carefully if you have diabetes and use moringa. Nov 24, 20 further studies by this group revealed that curcumin increased endothelin1 levels. Alloxan has been administered in single or multiple doses, through different routes. Alloxan and streptozotocin are the most prominent diabe togenic chemical. Periodontal disease in diabetic patients presents higher severity and prevalence. The effects of ethanol extracts on glucose tolerance tests were significant. Passiflora edulis, antidiabetic, hyperglycemia, alloxan mono hydrate introduction nsulin is the principal hormone secreted by.
International journal of research in pharmaceutical sciences. Alloxan diabetes and streptozotocin diabetes figure 1 shows a schematic diagram of the tetraphasic and triphasic blood glucose responses induced by alloxan and streptozotocin, respectively, when injected 22. Sprva je bilo o njej opravljenih le malo raziskav, nakar sta leta 1931 dva francoska kemika izolirala glikozida, ki dajeta stevii sladek okus. In vitro and in streptozotocin induced diabetic rats revealed that that oregano alleviated oxidative stress under. The health benefits of green tea for a wide variety of ailments, including different types of cancer, heart disease, and liver disease, were reported. Wang and ng 2001 reported that gossypol and alkaloids of corydalis yanhusuo might be responsible for it inhibitory activity on hiv virus. The streptozotocin induced rats with diabetics were administrated by oral intragastric intubation separately with low dose, middle dose, high dose of fenugreek extract, and metformin hcl for 6 weeks. Uses, side effects, interactions, dosage, and warning. Pdf estimation of glucose level and body weight in alloxan. The journal publishes novel research in the physiological and pharmacological sciences, including brain research, cardiovascularpulmonary interactions, hematology, immune response, inflammation, metabolism, oxidative stress, and phytotherapy.
Rosiglitazone attenuates arrhythmogenic atrial structural remodeling and af promotion in alloxan induced diabetic rabbits. Alloxaninduced diabetes, a common model for evaluating the. Alloxaninduced insulin release is, however, of short duration and is followed by complete suppression of the islet response to glucose, even when high concentrations 16. Fifth, curcumin enhanced cutaneous wound healing in rats and guinea pigs. Fabaceae leaves and flowers on alloxan induced diabetes in rats. The mechanisms of alloxan and streptozotocininduced diabetes. Diabetes induced by coxsackie virus infection is a direct. The proximate composition of chrysophyllum albidum seed methanol extract was found to contain crude protein 8. In spite of many antidiabetic drugs that are available, an adequate level of control remains challenging. For animals including mice, rats, rabbits, and dogs, a single dose of aqueous alloxan about 150 mgkg may be administered intravenously or intraperitoneally. Thirty nondiabetic control rats nc and 30 untreated. Mouse and rat models of diabetes also exist including obob and dbdb mice which are a type 2 diabetes model, and nonobese diabetic mice nod which are a model for type 1 diabetes. The first issue of the journal came out in 1969 and in 1997 it was published bimonthly. Antidiabetic activity of differently regioselective chitosan.
The gene that encodes glut4 was cloned and mapped in 1989. Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals. Andiroba oil on wound healing in rats with induced diabetes. In vitro and in vivo antidiabetic activity of the leaves of ravenala madagascariensis sonn. Alloxan mgkg, ip was used for the induction of diabetes in adult male wistar rats. Rats treated with fenugreek extract had an increase in body weight and a decrease in kidneybody weight ratio as compared with diabetic group. Effects of andiroba oil carapa guianensis on wound. Diabetes is usually induced around 57 days prior to the start of the experiment to ensure stable hyperglycaemia. Journal of basic and clinical physiology and pharmacology. Pdf antidiabetic activity of hf on alloxan induced diabetic rats. Popular in italian, spanish and mediterranean cooking, oregano is considered one of the best herbs to lower blood sugar levels. To test the effect of insulin treatment on the pharmacokinetics of metformin in rats with diabetes mellitus induced by alloxan dmia rats.
The responses are accompanied by corresponding inverse changes in plasma insulin and sequential ultrastructural. Many of these beneficial effects of green tea are related to its catechin, particularly epigallocatechin3gallate, content. Alloxaninduced diabetes triggers the development of. It has been successfully induced in a variety of animal species. It also publishes papers on cuttingedge techniques in cellular and molecular biology that link descriptive and behavioral studies with cellular and. The following results were reported from other studies. Hypoglycemic effects in alloxaninduced diabetic rats of the. It has been widely used to induce experimental diabetes in animals such as rabbits, rats, mice and dogs with different grades of disease severity by varying the dose of alloxan used 8. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal.
It is better to standardize it first by jain et al. Fourth, curcumin improved diabetes induced endothelial cell dysfunction through its antioxidant activity and pkc inhibition in stz induced diabetic rats and mice. Jayshree department of pharmacognosy, college of pharmacy, madras medical college, chennai600 003, india. There is evidence from in vitro and animal studies on the underlying mechanisms of green tea catechins and their. Ubikinoni koentsyymi q10 itsehoidon artikkelit tohtori.
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